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They were first used in the 1900s They can be used to reduce the amount of saliva is produced, and therefore can decrease drooling Most helpful to younger patients with PD whose chief complaint is a tremorAnticholinergic drugs block the action of a chemical messenger — acetylcholine — that sends signals to your brain that trigger abnormal bladder contractions associated with overactive bladder These bladder contractions can make you feel the need to urinate even when your bladder isn't fullThe prevalence of anticholinergic use in older adults ranges from 8% to 37% 15 This frequent use is despite the conclusions of professional organizations that the benefits of using these agents in older adults may be outweighed by the risks 68 A wellknown risk with anticholinergics is acute impairment in specific aspects of cognition (eg Anticholinergic Drug Burden And Delirium A Systematic Review Journal Of The American Medical Directors Association Anticholinergic side effects